Rapid Progression of Coronary Disease in Fabry Disease
Wenqi Li, Chunting Zhao, Mingya Liu · 2026
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Description
Wenqi Li, Chunting Zhao, and Mingya Liu describe rapid coronary disease progression in a genetic disorder in a 2026 case report. A forty-three-year-old man with classic Fabry disease developed exertional chest pain despite enzyme replacement therapy and well-controlled standard risk factors. Artery imaging showed severe disease in all three major coronary vessels, and ultrasound inside the arteries revealed several vulnerable plaques at risk of rupture.
Blood tests found autoantibodies and a raised inflammation marker, pointing to an active immune attack in the body. Treatment combined a catheter procedure, intensive cholesterol lowering, and the anti-inflammatory drug colchicine. The authors propose that Fabry disease itself strongly drives artery disease, with secondary inflammation speeding plaque growth beyond what standard risk scores capture. They urge close watching and inside-the-artery imaging in such patients.
Catalog record
| CREATOR | Wenqi Li, Chunting Zhao, Mingya Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14848 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |