CD45 as a multifunctional target in immune regulation and therapeutic delivery
Kaikai Zhao, Ruohan Yang, Mengli Li, Zhenzhong Zhang, Junjie Liu, Jinjin Shi, Xiu Zhao · 2026
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Description
Kaikai Zhao and colleagues review CD45 as both an immune regulator and a delivery target in a 2026 article. CD45 is an enzyme found on nearly all white blood cells, where it sets signaling thresholds that control cell activation. Its disruption is implicated in immune diseases and blood cancers. The review gathers mechanisms across immune cell types and the strategies built around them.
Approaches covered include changing CD45 levels, altering its shape, and redistributing it on the cell membrane. Because CD45 is specific to white cells and widely expressed, it also serves as an address for drug delivery, including antibody-drug conjugates and living cell carriers loaded through CD45 binding. The authors aim to connect basic immunology with practical therapeutic design.
Catalog record
| CREATOR | Kaikai Zhao, Ruohan Yang, Mengli Li, Zhenzhong Zhang, Junjie Liu, Jinjin Shi, Xiu Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70277 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |