Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels
Kelechi Ichie, Azuoma Asomugha, Izuchukwu Okafor · 2026
Read Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels by Kelechi Ichie, Azuoma Asomugha, Izuchukwu Okafor (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13523310.txt.
Description
Kelechi Ichie, Azuoma Asomugha, and Izuchukwu Okafor test whether age changes vulnerability to a Parkinson-linked weed killer in rats in a 2026 study. Sixty-three male rats were split into juvenile, young adult, and adult groups, each with control, exposed, and recovery subgroups. Paraquat was given twice weekly for three weeks, and recovery animals were then kept for two months. Behavior, brain tissue structure, and levels of the protein alpha-synuclein were measured.
Adult rats showed the clearest harm, with reduced movement and more prominent damage in the substantia nigra, the brain region lost in Parkinson disease. Tissue partly recovered after exposure stopped, yet residual changes persisted, especially in adults. Alpha-synuclein levels in brain and blood mostly did not track the damage, leading the authors to question blood levels as a stand-alone marker.
Catalog record
| CREATOR | Kelechi Ichie, Azuoma Asomugha, Izuchukwu Okafor |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40065 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |