Serum IL-38 and the rs7599662 polymorphism: novel biomarkers for pediatric idiopathic nephrotic syndrome
Sherin Khamis Hussein, Maha Hosni Morsi, Omayma O Abdelaleem, Doaa Ezzat Sayed Ahmed, Doha Elsayed Ahmed Hassanein, Marwa A Ali, Shaimaa Abdelbadie, Ahmed Mohamed Gamal EL Din Wahba, Asmaa Younis Elsary, Heba Safar, Reham Fares · 2026
Read Serum IL-38 and the rs7599662 polymorphism: novel biomarkers for pediatric idiopathic nephrotic syndrome by Sherin Khamis Hussein, Maha Hosni Morsi, Omayma O Abdelaleem, Doaa Ezzat Sayed Ahmed, Doha Elsayed Ahmed Hassanein, Marwa A Ali, Shaimaa Abdelbadie, Ahmed Mohamed Gamal EL Din Wahba, Asmaa Younis Elsary, Heba Safar, Reham Fares (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13523273.txt.
Description
Sherin Khamis Hussein and colleagues investigate serum IL-38 and a related gene variant as biomarkers for childhood idiopathic nephrotic syndrome. Their 2026 case-control study concerns the most common chronic glomerular disorder in children.
Eighty-eight child patients and seventy-four matched healthy controls took part. Serum IL-38 was measured by an enzyme assay, and a specific gene polymorphism was typed by real-time PCR. IL-38 levels were significantly lower in patients than controls. Levels also correlated negatively with age, systolic blood pressure, and urinary protein. Diagnostic performance was moderate. The authors explore whether this anti-inflammatory cytokine could help identify disease or predict treatment response.
Catalog record
| CREATOR | Sherin Khamis Hussein, Maha Hosni Morsi, Omayma O Abdelaleem, Doaa Ezzat Sayed Ahmed, Doha Elsayed Ahmed Hassanein, Marwa A Ali, Shaimaa Abdelbadie, Ahmed Mohamed Gamal EL Din Wahba, Asmaa Younis Elsary, Heba Safar, Reham Fares |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |