MicroRNA-18a-3p as a biomarker for neonatal respiratory distress syndrome and its effects in alveolar epithelial type II cells
Yujie Shi, Ye Jin, Hui Yu · 2026
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Description
Yujie Shi, Ye Jin, and Hui Yu investigate a small RNA as a marker for newborn breathing disease in a 2026 study. Neonatal respiratory distress syndrome is a major cause of illness and death, especially in preterm infants. Blood and amniotic fluid from thirty-five affected newborns and thirty-five healthy controls were compared for levels of one microRNA, and cell experiments tested its effect on lung surface cells.
The microRNA was elevated in both blood and amniotic fluid of affected newborns, and each fluid distinguished cases from controls with good accuracy. Blocking the microRNA in lung cells improved cell survival and raised output of a key surfactant protein, whose gene it directly regulates. The authors suggest the molecule participates in fetal lung development and could serve as a biomarker for the syndrome.
Catalog record
| CREATOR | Yujie Shi, Ye Jin, Hui Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23681 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |