The NAT10/c-Myc positive feedback loop orchestrates tRNA ac4C modification and OTUB1-mediated protein stabilization to drive anaplastic thyroid carcinoma progression
Bo Wei, Haixi Zhao, Shi Chang, Wenlong Wang · 2026
Read The NAT10/c-Myc positive feedback loop orchestrates tRNA ac4C modification and OTUB1-mediated protein stabilization to drive anaplastic thyroid carcinoma progression by Bo Wei, Haixi Zhao, Shi Chang, Wenlong Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13523248.txt.
Description
Bo Wei, Haixi Zhao, Shi Chang, and Wenlong Wang uncover a self-reinforcing loop driving an aggressive thyroid cancer in a 2026 study. Anaplastic thyroid carcinoma grows fast and has few treatment options. The enzyme NAT10, which modifies transfer RNA, was found at high levels in these tumors and linked to poor prognosis. Cell, animal, and multi-omics experiments traced how it interacts with the growth driver c-Myc.
Each partner boosts the other: c-Myc switches on the NAT10 gene, while NAT10 raises c-Myc production and stability through RNA modification and a partner enzyme. Blocking NAT10 with a small molecule suppressed tumor growth. Combining that blocker with a standard chemotherapy drug gave synergistic effects in cells and animals. The authors propose the loop as a treatment target for this hard-to-treat cancer.
Catalog record
| CREATOR | Bo Wei, Haixi Zhao, Shi Chang, Wenlong Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58548 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |