Mitochondrial proteases maintain cellular protein homeostasis and tissue integrity
Kexin Shi, Hao Liu, Hong Xu, Weina Shang, Liquan Wang, Chao Tong · 2026
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Description
Kexin Shi and colleagues systematically test mitochondrial proteases in fruit flies in a 2026 study. Proteases inside mitochondria, the cell's energy units, keep mitochondrial proteins in good order and help import new ones. Fifteen conserved proteases were disrupted or boosted, in whole animals and in specific tissues such as eye, muscle, and fat body.
Disrupting certain proteases caused sterility or death, while tissue-specific loss produced protein clumps, structural defects, and age-related degeneration. Two protease losses strongly increased cleanup of damaged mitochondria. Loss of some proteases also worsened clumping of a Huntington disease protein in the wider cell, while boosting one protease suppressed that clumping and its toxicity. The work maps how mitochondrial quality control shapes protein health across the whole cell.
Catalog record
| CREATOR | Kexin Shi, Hao Liu, Hong Xu, Weina Shang, Liquan Wang, Chao Tong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74563 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |