Impact of Free Water Correction on the Mean Diffusivity of Glioblastoma is Regional and b-value Dependent: A Retrospective Study on Open-source Datasets
Shu Matsushita, Hiroyuki Tatekawa, Daisuke Horiuchi, Tatsushi Oura, Natsuko Atsukawa, Ayako Omori, Hirotaka Takita, Taro Shimono, Daiju Ueda, Yukio Miki · 2026
Read Impact of Free Water Correction on the Mean Diffusivity of Glioblastoma is Regional and b-value Dependent: A Retrospective Study on Open-source Datasets by Shu Matsushita, Hiroyuki Tatekawa, Daisuke Horiuchi, Tatsushi Oura, Natsuko Atsukawa, Ayako Omori, Hirotaka Takita, Taro Shimono, Daiju Ueda, Yukio Miki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13522939.txt.
Description
Shu Matsushita and colleagues examine a correction technique for brain tumor imaging in a 2026 retrospective study using two open datasets totaling seven hundred eighty-seven patients with glioblastoma. Diffusion imaging measures how water moves in tissue, and free water from swelling can distort those values. Maps with and without free-water correction were compared in the bright tumor core and in surrounding altered regions, under two different scan settings.
Corrected values were lower in tumor cores than in surrounding regions in both datasets. Which region changed most after correction flipped between datasets, tracking the different scan settings rather than tumor biology alone. Values with and without correction correlated very strongly. Neither version predicted survival. The authors warn that scan settings must be considered when interpreting the correction in tumor studies.
Catalog record
| CREATOR | Shu Matsushita, Hiroyuki Tatekawa, Daisuke Horiuchi, Tatsushi Oura, Natsuko Atsukawa, Ayako Omori, Hirotaka Takita, Taro Shimono, Daiju Ueda, Yukio Miki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24987 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |