Resting State Functional Connectivity Among Cortical and Subcortical Grey Matter Structures Can Distinguish Fallers in Parkinson's Disease
Rodrigo Vitorio, Korey P Wylie, Justin W Andrushko · 2026
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Description
Rodrigo Vitorio, Korey Wylie and Justin Andrushko hunt for brain connectivity patterns that separate Parkinson's patients who fall from those who do not. Falls are common and harmful in this disease, and their brain basis is murky. Resting brain scans from fifty-eight people with mild to moderate disease, twenty-three fallers and thirty-five non-fallers, fed a search over region pairs tied to gait and balance.
Two links kept surfacing in the best models: a frontal region to the hypothalamus, and the touch cortex to a deep movement nucleus. Both links were weaker in fallers. Adding a third link, frontal cortex to thalamus, told the groups apart with strong accuracy. The pairs may serve as targets for fall prevention work.
Catalog record
| CREATOR | Rodrigo Vitorio, Korey P Wylie, Justin W Andrushko |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |