Overcoming the cytosine base editing barrier: Virus‐like particles with uracil‐DNA glycosylase inhibition unlocking the clinical potential
Yuqing Wu, Xingyu Zhu, Junjie Zhu, Jia Chen, Jiaxu Hong · 2026
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Description
Yuqing Wu and co-authors review a delivery trick that may carry gene editors into the body more safely. Most disease-causing variants are single-letter swaps, and base editors can fix them without cutting both DNA strands. Getting the editors to the right tissue is the hard part.
The usual virus carriers linger and raise safety worries. Fat bubbles reach mainly the liver. Virus-like particles deliver briefly and more broadly, but a cellular enzyme guards the target base and blunts one editor type. Blocking that enzyme inside the particle lifts the block. The review weighs the design's clinical promise. Delivery, as ever in gene therapy, is the real invention.
Catalog record
| CREATOR | Yuqing Wu, Xingyu Zhu, Junjie Zhu, Jia Chen, Jiaxu Hong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |