Efficacy and Safety of Celecoxib Combined with Gabapentin for Head and Facial Pain in Nasopharyngeal Carcinoma: A Retrospective Cohort Study
Xiangrong Cao, Linzong Xu, Weiwei Ta · 2026
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Description
Xiangrong Cao, Linzong Xu, and Weiwei Ta tested a pain strategy that spares opioids in patients with nasopharyngeal carcinoma, a throat cancer whose spread causes severe head and face pain. The pain mixes nerve damage and inflammation, so the team combined two non-opioid drugs aimed at each side: celecoxib and gabapentin. They compared thirty patients on the pair with thirty on extended-release oxycodone, reviewing the first two days of records.
The combined group reported a greater drop in pain scores at forty-eight hours. Their sleep improved far more, by the study's insomnia scale. Nausea and vomiting were absent in the combined group against twenty percent on opioids, while other side effects matched. The authors call the pair an effective opioid-sparing option, while stressing the study is small and backward-looking. Prospective trials, they say, should test whether the early advantage holds.
Catalog record
| CREATOR | Xiangrong Cao, Linzong Xu, Weiwei Ta |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |