Koumine inhibits osteoclastogenesis and prevents ovariectomy-induced bone loss via suppression of the MAPK signaling pathways
Xiang Zhang, Yang Wu, Kai-qi Jiang, Bang-sheng Cui, Jiong-Ming You · 2026
Read Koumine inhibits osteoclastogenesis and prevents ovariectomy-induced bone loss via suppression of the MAPK signaling pathways by Xiang Zhang, Yang Wu, Kai-qi Jiang, Bang-sheng Cui, Jiong-Ming You (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13522517.txt.
Description
Xiang Zhang and colleagues test a plant compound against bone loss in a 2026 study of cells and mice. The compound, koumine, comes from a medicinal plant and was applied to bone-eating cells grown from mouse bone marrow. Excess activity of those cells drives diseases such as osteoporosis, where bone thins and breaks more easily.
Koumine reduced formation of the bone-eating cells and their resorption activity in a dose-dependent way, without killing the cells or harming bone-building cells. It dampened a key signaling pathway and lowered several proteins needed for bone breakdown. In mice that had lost ovarian hormone production, treatment prevented bone loss, improved inner bone structure, and reduced cell numbers. The authors propose koumine as a candidate for bone-loss therapy.
Catalog record
| CREATOR | Xiang Zhang, Yang Wu, Kai-qi Jiang, Bang-sheng Cui, Jiong-Ming You |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46909 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |