A phase I study evaluating subcutaneous administration of the monoclonal antibody programmed cell death protein-1 (PD-1) inhibitor cetrelimab (JNJ-63723283) in patients with advanced solid malignancies
Piotr Rutkowski, Dariusz M. Kowalski, Victor Moreno, Aitana Calvo, Fiona Thistlethwaite, Ruth Plummer, Douglas Steinbach, John Loffredo, Sydney Akapeme, Daniel Jonathan, Vinod Philip, Angela Girvin, Shalaka Hampras, Peter Hellemans, Iurie Bulat · 2026
Read A phase I study evaluating subcutaneous administration of the monoclonal antibody programmed cell death protein-1 (PD-1) inhibitor cetrelimab (JNJ-63723283) in patients with advanced solid malignancies by Piotr Rutkowski, Dariusz M. Kowalski, Victor Moreno, Aitana Calvo, Fiona Thistlethwaite, Ruth Plummer, Douglas Steinbach, John Loffredo, Sydney Akapeme, Daniel Jonathan, Vinod Philip, Angela Girvin, Shalaka Hampras, Peter Hellemans, Iurie Bulat (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13522328.txt.
Description
Piotr Rutkowski and colleagues test in 2026 under-skin delivery of cetrelimab, a PD-1 blocking antibody, for advanced solid tumours in a phase I study. Participants had exhausted or lacked standard options and had never received checkpoint blockade before.
Thirty patients joined two parts testing a dilute then a concentrated formula, with a loading dose added in the second part. Median treatment lasted about two months in a heavily pretreated group. Drug-linked side effects affected 70 percent, with no drug-linked serious events or systemic infusion reactions. Two durable responses appeared, while loading dosing reached target exposure faster, supporting under-skin delivery for later trials.
Catalog record
| CREATOR | Piotr Rutkowski, Dariusz M. Kowalski, Victor Moreno, Aitana Calvo, Fiona Thistlethwaite, Ruth Plummer, Douglas Steinbach, John Loffredo, Sydney Akapeme, Daniel Jonathan, Vinod Philip, Angela Girvin, Shalaka Hampras, Peter Hellemans, Iurie Bulat |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46580 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |