A male rat model integrating hypertension, chronic cerebral hypoperfusion, and aging recapitulates multimodal cerebral small vessel disease phenotypes
Zhiwei Feng, Shan Han, Yanyi Li, Zhenzhen Li, Yige Tu, Bin Wu, Shengjie Zhu, Qin Zheng, Wenjun Sun · 2026
Read A male rat model integrating hypertension, chronic cerebral hypoperfusion, and aging recapitulates multimodal cerebral small vessel disease phenotypes by Zhiwei Feng, Shan Han, Yanyi Li, Zhenzhen Li, Yige Tu, Bin Wu, Shengjie Zhu, Qin Zheng, Wenjun Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13522228.txt.
Description
Zhiwei Feng and co-authors build a rat model that joins three drivers of cerebral small vessel disease: high blood pressure, long term low brain blood flow, and aging. Published in 2026, the study notes that single insult models miss how the disease forms in people. Male rats were split into four groups, from normal controls to the full triple insult group.
The triple insult rats did worst on maze learning, movement, and balance tests. Scans showed swollen ventricles and shrunken brain regions, and white matter fibers were damaged. Stains showed myelin loss and loose, deformed sheaths. Blood tests shifted for markers of barrier damage, inflammation, and nerve injury. Effects grew step by step as each insult was added.
Catalog record
| CREATOR | Zhiwei Feng, Shan Han, Yanyi Li, Zhenzhen Li, Yige Tu, Bin Wu, Shengjie Zhu, Qin Zheng, Wenjun Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |