Therapeutic Challenges and Future Breakthroughs in Amyotrophic Lateral Sclerosis: From Precision Medicine to Innovative Trial Design
Yutong Wei, Jie Wang, Yanan Ji, Tongxin Shang, Yuntian Shen, Hualin Sun, Yong Cai · 2026
Read Therapeutic Challenges and Future Breakthroughs in Amyotrophic Lateral Sclerosis: From Precision Medicine to Innovative Trial Design by Yutong Wei, Jie Wang, Yanan Ji, Tongxin Shang, Yuntian Shen, Hualin Sun, Yong Cai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13522104.txt.
Description
Wei and six co-authors review why treating amyotrophic lateral sclerosis, a fatal nerve disease, has proved so hard. Only two drugs won approval for years, and one later drug was withdrawn after a big trial failed. The review lists the limits of current care and four reasons trials keep failing.
Those reasons are the disease's variety, weak biomarkers, animal models that mislead, and flawed trial designs. New hopes include gene therapy for one inherited form, protein cleanup, calming inflammation, and energy support. Platform trials that test many drugs at once are reshaping the field. The authors see care moving toward treatment matched to each patient's subtype.
Catalog record
| CREATOR | Yutong Wei, Jie Wang, Yanan Ji, Tongxin Shang, Yuntian Shen, Hualin Sun, Yong Cai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |