Context-dependent effectiveness of autologous platelet concentrates in regenerative endodontic procedures and periapical surgery: A systematic review and meta-analysis
Shivkumar P. Mantri, Niharika A. Gupta, Sneha S. Mantri · 2026
Read Context-dependent effectiveness of autologous platelet concentrates in regenerative endodontic procedures and periapical surgery: A systematic review and meta-analysis by Shivkumar P. Mantri, Niharika A. Gupta, Sneha S. Mantri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13521542.txt.
Description
Mantri and colleagues reviewed the evidence in 2026 on autologous platelet concentrates, meaning healing products made from a patient's own blood, in regenerative dental procedures and root-end surgery. Their systematic review and meta-analysis pooled 39 clinical studies comparing platelet-rich plasma or fibrin against standard scaffolds and treatments.
In young teeth with open roots, platelet products healed no better than a simple blood clot scaffold, and root growth was similar. In mature teeth, X-ray healing also showed no clear gain. The clear benefit appeared in periapical surgery, where platelet products nearly doubled the rate of good radiographic healing as an added material. Pain relief after surgery trended lower but was not proven, so the authors frame these products as helpful add-ons, not replacements.
Catalog record
| CREATOR | Shivkumar P. Mantri, Niharika A. Gupta, Sneha S. Mantri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |