Evaluation of cytotoxicity, setting time, and mineralization potential of mineral trioxide aggregate with Nigella sativa aqueous extract: An in vitro study
Shanmugapriya Karunakaran, K. E. Selvendran, Hafeela Farhana, Ashok Leburu, Madhuram Krishnamurthy · 2026
Read Evaluation of cytotoxicity, setting time, and mineralization potential of mineral trioxide aggregate with Nigella sativa aqueous extract: An in vitro study by Shanmugapriya Karunakaran, K. E. Selvendran, Hafeela Farhana, Ashok Leburu, Madhuram Krishnamurthy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13521527.txt.
Description
Karunakaran and colleagues tested in 2026 whether an extract of Nigella sativa, known as black seed, improves a dental repair material called mineral trioxide aggregate. Working in the lab, they mixed the extract into the material at 30 and 50 percent levels and checked cell safety, setting time, and mineral formation on bone-like cells.
The extract raised cell viability as its share grew, with the 50 percent mix giving the highest values. Both extract mixes set faster, at the start and at final hardening, than the plain material. Mineral deposits also increased, again most strongly at the higher level. The authors suggest the black seed extract could be a useful additive for root-end dental treatments, pending further testing.
Catalog record
| CREATOR | Shanmugapriya Karunakaran, K. E. Selvendran, Hafeela Farhana, Ashok Leburu, Madhuram Krishnamurthy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |