CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity
Lauren Evans, Maria Conde Poole, Cenk Celik, Harshita Mishra, Michael J Pitcher, Anita Grigoriadis, Maria Secrier, Patricia Barral · 2026
Read CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity by Lauren Evans, Maria Conde Poole, Cenk Celik, Harshita Mishra, Michael J Pitcher, Anita Grigoriadis, Maria Secrier, Patricia Barral (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13521511.txt.
Description
Lauren Evans and co-authors study a lipid-presenting molecule in breast cancer in this 2026 paper. The molecule, CD1d, sits on immune cells inside tumors. Myeloid cells there can either fight the tumor or shield it. What sets their behavior was unclear. The team removed or blocked CD1d in several mouse breast cancer models.
Tumors grew more slowly without CD1d. The myeloid mix inside shifted toward inflammatory fighters. A standard immunotherapy drug also worked better alongside the blockade. The effect traced to the myeloid cells themselves, in mice and human samples alike. A gene pattern from the work matched patient outcomes, marking CD1d as a drug target.
Catalog record
| CREATOR | Lauren Evans, Maria Conde Poole, Cenk Celik, Harshita Mishra, Michael J Pitcher, Anita Grigoriadis, Maria Secrier, Patricia Barral |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |