DNA methylation profiling of the granulosa layer reveals epigenetic features of excessive hierarchical follicle development in chickens
Zihan Xu, Yanyue Pan, Ranran Zhu, Yuxiang Jiang, Ziyi Lian, Bingjie Zhang, Haonan Tang, Wanyi Xiong, Xiuping Wang, Jiankui Wang, Xuemei Deng · 2026
Read DNA methylation profiling of the granulosa layer reveals epigenetic features of excessive hierarchical follicle development in chickens by Zihan Xu, Yanyue Pan, Ranran Zhu, Yuxiang Jiang, Ziyi Lian, Bingjie Zhang, Haonan Tang, Wanyi Xiong, Xiuping Wang, Jiankui Wang, Xuemei Deng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13521220.txt.
Description
Zihan Xu and colleagues mapped chemical marks on DNA in the egg-supporting cell layer of chickens that grow too many follicles at once. Published in 2026, the study tracked a trait in which extra follicles mature together, harming egg laying and fertility. Sound scans followed the trait early in laying, and full-genome sequencing mapped DNA marks in small yellow follicle nurse cells.
The work delivers the first nurse-cell DNA-mark profile for this trait. Gene-switch regions that lost their marks pointed to Wnt, calcium, and cell-stickiness routes, suggesting ways gene control slips. The trait itself wavered during growth and cut egg laying. Readers gain a gene-control foothold on a poultry breeding problem, with gene-level leads for future checks.
Catalog record
| CREATOR | Zihan Xu, Yanyue Pan, Ranran Zhu, Yuxiang Jiang, Ziyi Lian, Bingjie Zhang, Haonan Tang, Wanyi Xiong, Xiuping Wang, Jiankui Wang, Xuemei Deng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |