CAR design equips diverse immune cells with unique antigen-specific activation identities
Ayano Sugiyama-Finnis, Takaharu Kimura, Kiyoko Izawa, Yuko Kawano, Takao Yogo, Hyojung Jeon, Tsuyoshi Fukushima, Ryoji Ito, Satoshi Yamazaki · 2026
Read CAR design equips diverse immune cells with unique antigen-specific activation identities by Ayano Sugiyama-Finnis, Takaharu Kimura, Kiyoko Izawa, Yuko Kawano, Takao Yogo, Hyojung Jeon, Tsuyoshi Fukushima, Ryoji Ito, Satoshi Yamazaki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13521014.txt.
Description
Ayano Sugiyama-Finnis and colleagues compare in 2026 how engineered chimeric antigen receptors switch on different immune cell types grown from blood stem cells. Receptor therapy succeeded first in T cells, while designs tuned for other lineages may behave unevenly across cell families.
Stem-derived T cells, natural killer cells and myeloid cells activated across several receptor designs, whereas B cells responded only to certain designs. Gene programmes showed lineage as the dominant influence, with design tuning growth, inflammation and cytokine signals inside each lineage. Single-cell tracking linked design choices to downstream programmes. Small group sizes make the work exploratory, yet useful for tailoring future cell therapies.
Catalog record
| CREATOR | Ayano Sugiyama-Finnis, Takaharu Kimura, Kiyoko Izawa, Yuko Kawano, Takao Yogo, Hyojung Jeon, Tsuyoshi Fukushima, Ryoji Ito, Satoshi Yamazaki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 122 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |