DLL1-mediated ferroptosis resistance via the Notch-Nrf2/GPX4 axis drives cisplatin resistance in ovarian cancer
Dan Ye, Gaoting Huang, Xingcheng Yan, Lezi Suntan, Haoran Shen, Jian Shen · 2026
Read DLL1-mediated ferroptosis resistance via the Notch-Nrf2/GPX4 axis drives cisplatin resistance in ovarian cancer by Dan Ye, Gaoting Huang, Xingcheng Yan, Lezi Suntan, Haoran Shen, Jian Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13520430.txt.
Description
Dan Ye and colleagues show in 2026 that a signalling protein called DLL1 helps ovarian cancer resist the chemotherapy drug cisplatin by blocking a form of iron-driven cell death. Ovarian cancer often returns after cisplatin, so understanding resistance routes matters for new combinations.
DLL1 levels were higher in tumour tissue and tracked with poorer outlook. Lowering DLL1 slowed growth and movement while triggering the iron-driven death pathway, with more lipid damage and faulty mitochondria. A protective Nrf2 and GPX4 axis sat downstream. In animals, targeting DLL1 alongside a death inducer shrank resistant tumours, nominating DLL1 as both marker and drug target.
Catalog record
| CREATOR | Dan Ye, Gaoting Huang, Xingcheng Yan, Lezi Suntan, Haoran Shen, Jian Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76470 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |