Innovative multi-epitope vaccine engineering for dual protection against Salmonella and Shigella leveraging FliC flagellin protein adjuvant properties: an immunoinformatics-based approach
Elnaz Afshari, Neda Soleimani · 2026
Read Innovative multi-epitope vaccine engineering for dual protection against Salmonella and Shigella leveraging FliC flagellin protein adjuvant properties: an immunoinformatics-based approach by Elnaz Afshari, Neda Soleimani (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13520335.txt.
Description
Elnaz Afshari and Neda Soleimani design on paper in 2026 a single vaccine aimed at both Salmonella and Shigella, two food-borne bacteria with no licensed vaccine yet. Their computer-based design joins short immune-triggering fragments from six shared bacterial proteins.
Fragments were screened for immune coverage, safety signals and stability, then linked onto a bacterial flagellin scaffold that also boosts immunity. Modelling suggested a stable, water-friendly construct of suitable size, with favourable structure checks. Immune simulation predicted a strong response. Because all work so far is computational, laboratory and animal testing would be the essential next step before any health claim.
Catalog record
| CREATOR | Elnaz Afshari, Neda Soleimani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91740 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |