Vitamin A-coupled MSCs- derived extracellular vesicles relieve acute liver injury by targeting hepatic stellate cells to deliver REDD1
Tingjuan Huang, Zixu Li, Xinrui Shi, Xinyu Feng, Linyun Wei, Xiaonan Li, Junjie Ren · 2026
Read Vitamin A-coupled MSCs- derived extracellular vesicles relieve acute liver injury by targeting hepatic stellate cells to deliver REDD1 by Tingjuan Huang, Zixu Li, Xinrui Shi, Xinyu Feng, Linyun Wei, Xiaonan Li, Junjie Ren (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13520313.txt.
Description
Tingjuan Huang and colleagues report in 2026 a targeted delivery system for acute liver injury using tiny vesicles shed by stem cells. Plain vesicles spread widely in the liver, so the team adds vitamin A to steer them toward stellate cells that drive scarring, carrying a gene called REDD1.
Lab tests showed stronger uptake by activated stellate cells, while animal tests showed better liver build-up. Treatment quieted stellate cell activity, lowered inflammation and cell death, and improved liver function and scarring measures. The design pairs a natural targeting trick with gene delivery, offering a template for more precise liver medicines.
Catalog record
| CREATOR | Tingjuan Huang, Zixu Li, Xinrui Shi, Xinyu Feng, Linyun Wei, Xiaonan Li, Junjie Ren |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54257 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |