Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia
Jorge Gonzalez, Joshua Wageman, Laura Buchanan, Tro Kalayjian, Matthew Calkins, Erin Saner, Adrian Soto-Mota · 2026
Read Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia by Jorge Gonzalez, Joshua Wageman, Laura Buchanan, Tro Kalayjian, Matthew Calkins, Erin Saner, Adrian Soto-Mota (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13520245.txt.
Description
Jorge Gonzalez and co-authors report fourteen patients whose cholesterol soared on a ketogenic diet and then fell further than expected on a gut-blocking drug. Their 2026 case series starts from a known puzzle: the diet lifts LDL cholesterol sharply in some people, for reasons not yet pinned down. The drug used, ezetimibe, blocks cholesterol uptake in the gut.
Genetic checks in a subset found no double dose of the variants behind a known absorption disorder. The team proposes a chain: chronically low insulin reshapes how the liver packages cholesterol and how the gut handles it, through named enzymes and transport proteins. The size of the drop hints that absorption carries much of the blame. They call for prospective tests of tailored lipid care.
Catalog record
| CREATOR | Jorge Gonzalez, Joshua Wageman, Laura Buchanan, Tro Kalayjian, Matthew Calkins, Erin Saner, Adrian Soto-Mota |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |