Turmeric-derived nanovesicles reprogram pathological NETosis to mitigate inflammatory bone loss
Ming Wang, Kamoran Tuerhong, Ying Xie, Qi Huang, Qianyu Zhang, Kehao Liu, Huiya Wang, Xiaoke Su, Xiaoyang Luo, Xinzhi Jiang, Haixia Dang, Danfeng Shen, Yuzhou Li, Sheng Yang · 2026
Read Turmeric-derived nanovesicles reprogram pathological NETosis to mitigate inflammatory bone loss by Ming Wang, Kamoran Tuerhong, Ying Xie, Qi Huang, Qianyu Zhang, Kehao Liu, Huiya Wang, Xiaoke Su, Xiaoyang Luo, Xinzhi Jiang, Haixia Dang, Danfeng Shen, Yuzhou Li, Sheng Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13520241.txt.
Description
Ming Wang leads a large team in 2026 building turmeric-derived nanovesicles to calm the runaway immune response that erodes bone in gum disease. Excess web-like traps cast out by neutrophils, called NETs, feed inflammation and bone-eating cell activity in a self-amplifying loop. Single-cell data from public sets flagged faulty trap formation as a treatment target.
The tiny plant vesicles, loaded with turmeric's own active compounds, were eagerly taken up by neutrophils. Treated cells cast far fewer traps, showing lower oxidative stress markers and less expelled DNA. Gene profiles confirmed quieter trap pathways alongside stronger antioxidant defenses. In mice with periodontitis, vesicles gathered at inflamed sites, slowed bone loss, and preserved bone structure.
Catalog record
| CREATOR | Ming Wang, Kamoran Tuerhong, Ying Xie, Qi Huang, Qianyu Zhang, Kehao Liu, Huiya Wang, Xiaoke Su, Xiaoyang Luo, Xinzhi Jiang, Haixia Dang, Danfeng Shen, Yuzhou Li, Sheng Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86786 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |