An injectable SFMA/HA-E hydrogel for sustained delivery of hucMSC-derived exosomes promotes myocardial repair after infarction
Gang Deng, Shuoji Zhu, Qing Ouyang, Xuyu He, Yu-Sen Ou, Haotao Su, Linhui Jiang, Jinsong Huang, Xiang Long, Min Wu, Ge Li, Changjiang Yu, Chen Lu, Ping Zhu, Moussa Ide Nasser · 2026
Read An injectable SFMA/HA-E hydrogel for sustained delivery of hucMSC-derived exosomes promotes myocardial repair after infarction by Gang Deng, Shuoji Zhu, Qing Ouyang, Xuyu He, Yu-Sen Ou, Haotao Su, Linhui Jiang, Jinsong Huang, Xiang Long, Min Wu, Ge Li, Changjiang Yu, Chen Lu, Ping Zhu, Moussa Ide Nasser (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13520215.txt.
Description
Gang Deng leads a team in 2026 testing an injectable gel that slowly releases healing vesicles into heart attack-damaged rat hearts. Exosomes from human umbilical cord stem cells show repair promise, yet the body clears them too fast to help. The gel blends silk fibroin with a tea-compound-grafted hyaluronic acid and hardens with light after injection.
In cell tests under low oxygen, the vesicles improved survival, movement, and tube formation. A single injection into injured hearts lifted pumping efficiency from about 31 percent in untreated animals to about 71 percent, cut scarring, and reduced cell death. New vessel growth rose, immune cells shifted toward a repair-friendly type, and the electrical coupling protein connexin 43 increased.
Catalog record
| CREATOR | Gang Deng, Shuoji Zhu, Qing Ouyang, Xuyu He, Yu-Sen Ou, Haotao Su, Linhui Jiang, Jinsong Huang, Xiang Long, Min Wu, Ge Li, Changjiang Yu, Chen Lu, Ping Zhu, Moussa Ide Nasser |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51481 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |