From mechanical adaptation to innate immune reprogramming in osteoarthritis: a load-immunity framework
Shiguo Zuo, Lijun He, Zhiying Hou, Quanliang Tian, Yilong Yang, Weichen Huang · 2026
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Description
Osteoarthritis (OA) is a whole-joint disease in which mechanical exposure and low-grade sterile inflammation interact, but their coexistence does not by itself explain why a normally adaptive response becomes self-sustaining. This Mini Review therefore focuses on a narrower question: how do specific loading conditions push joint-resident cells from reversible mechanoadaptation into persistent innate immune dysregulation?
Catalog record
| CREATOR | Shiguo Zuo, Lijun He, Zhiying Hou, Quanliang Tian, Yilong Yang, Weichen Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |