Measuring Brain Stiffness in Normal Adults According to Age and Sex Using Virtual MR Elastography: A Preliminary Study
Jung Hyun Park, Miran Han, Miseon Yeon, Jin Wook Choi · 2026
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Description
Jung Hyun Park and colleagues measured how brain stiffness changes with age and sex in healthy adults. Published in 2026, the study reviewed 96 adults aged thirty-one to eighty who had MRI scans during routine checkups, using a virtual elastography method built from diffusion imaging. Brain stiffness reflects tissue makeup and can shift in tumors and diseases such as Alzheimer disease and multiple sclerosis.
Deep structures like the thalamus and basal ganglia ran stiffer than the outer lobes, with the occipital lobe stiffest among lobes and the temporal lobe softest. Stiffness eased slightly with age overall, most sharply in cerebral gray matter, while the hippocampus softened markedly after age fifty. Sex gaps appeared only in the parietal lobe and basal ganglia. The work supplies a healthy baseline against which disease-related softening can be judged.
Catalog record
| CREATOR | Jung Hyun Park, Miran Han, Miseon Yeon, Jin Wook Choi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |