Sex-dependent dopaminergic vulnerability may contribute to sex differences in Parkinson’s disease risk
Tamir Eisenstein, Frederik J Lange, Michele T M Hu, Johannes C Klein · 2026
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Description
Men are more likely than women to develop Parkinson’s disease, yet the biological basis of this sex difference in Parkinson’s disease risk remains unresolved. The nigrosome-1 (NG-1), a dopaminergic subregion of the substantia nigra, is selectively vulnerable to degeneration and iron accumulation in Parkinson’s disease, therefore representing a plausible locus for sex-linked vulnerability.
Catalog record
| CREATOR | Tamir Eisenstein, Frederik J Lange, Michele T M Hu, Johannes C Klein |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |