Pharmacological Treatment of Olfactory Reference Disorder: A Systematic Review and Historical Analysis of Treatment Patterns
Ligia M Fonseca, Verônica Hühne, Murilo Branco, Inês M Salles-Fonseca, Gabriela B de Menezesa, Leonardo F Fontenelle · 2026
Read Pharmacological Treatment of Olfactory Reference Disorder: A Systematic Review and Historical Analysis of Treatment Patterns by Ligia M Fonseca, Verônica Hühne, Murilo Branco, Inês M Salles-Fonseca, Gabriela B de Menezesa, Leonardo F Fontenelle (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13519273.txt.
Description
Fonseca and colleagues reviewed drug treatment for olfactory reference disorder in a 2026 analysis. The disorder is the conviction that one emits a foul body odor others barely notice. The analysis also traces how prescribing changed over decades. Following standard review guidelines, the team extracted patient, symptom, and treatment details from every report they could find on medicines for this condition.
Fonseca located 52 studies covering 87 patients, almost all single case reports or small series, with no controlled trials at all. Serotonin reuptake inhibitors were used in about three fifths of cases and antipsychotics in about half. These inhibitors are a class of antidepressants. The reported response rate ran above eighty percent, which the authors discount for publication bias. Antipsychotics dominated earlier decades, while serotonin drugs took over after the nineteen nineties as the disorder was reclassified within the obsessive-compulsive spectrum, and no patient feature reliably predicted response.
Catalog record
| CREATOR | Ligia M Fonseca, Verônica Hühne, Murilo Branco, Inês M Salles-Fonseca, Gabriela B de Menezesa, Leonardo F Fontenelle |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |