Glucocorticoid-induced Leucine Zipper (GILZ) is a novel secreted protein by intestinal L-cells and is dysregulated during active ulcerative colitis
Lucrezia Rosati, Giuseppe Leoncini, Luigi Cari, Maria Rosaria Sette, Martina Procaccini, Giuseppe Nocentini, Vincenzo Villanacci, Carlo Riccardi, Graziella Migliorati, Simona Ronchetti · 2026
Read Glucocorticoid-induced Leucine Zipper (GILZ) is a novel secreted protein by intestinal L-cells and is dysregulated during active ulcerative colitis by Lucrezia Rosati, Giuseppe Leoncini, Luigi Cari, Maria Rosaria Sette, Martina Procaccini, Giuseppe Nocentini, Vincenzo Villanacci, Carlo Riccardi, Graziella Migliorati, Simona Ronchetti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13518978.txt.
Description
Lucrezia Rosati leads a ten-author team identifying in 2026 a new secreted product of intestinal L-cells: GILZ, a protein best known for carrying out the calming effects of steroid hormones. L-cells are hormone-making gut cells that release GLP-1, a signal tied to appetite and blood sugar. Whether they also shipped GILZ, and what inflammation does to that shipping, was unknown.
GILZ sat inside granules partly shared with GLP-1 vesicles in L-cells at every maturity stage. Colon biopsies from active ulcerative colitis showed fewer hormone cells overall, and GILZ-bearing L-cells dropped sharply, recovering only partly when disease quieted. Lab tests showed L-cell secretions damped an inflammatory signal from gut lining cells, an effect that faded when GILZ was silenced.
Catalog record
| CREATOR | Lucrezia Rosati, Giuseppe Leoncini, Luigi Cari, Maria Rosaria Sette, Martina Procaccini, Giuseppe Nocentini, Vincenzo Villanacci, Carlo Riccardi, Graziella Migliorati, Simona Ronchetti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45248 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |