Targeting STAT3-mediated lipid metabolism reprogramming overcomes chemoresistance in acute myeloid leukemia
Keren Peng, Jianshan Mo, Zhenjiao Yang, Wen Ding, Jiayu Yan, Shumin Ouyang, Minyuan Lu, Kai Zhu, Hongru Yao, Huiqin Chen, Xiongjun Xu, Peibin Yue, Jinjian Lu, Yuanxiang Wang, Shanyi Zhang, Yandong Wang, Xiaolei Zhang · 2026
Read Targeting STAT3-mediated lipid metabolism reprogramming overcomes chemoresistance in acute myeloid leukemia by Keren Peng, Jianshan Mo, Zhenjiao Yang, Wen Ding, Jiayu Yan, Shumin Ouyang, Minyuan Lu, Kai Zhu, Hongru Yao, Huiqin Chen, Xiongjun Xu, Peibin Yue, Jinjian Lu, Yuanxiang Wang, Shanyi Zhang, Yandong Wang, Xiaolei Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13518950.txt.
Description
Keren Peng and a large team attack chemotherapy resistance in acute myeloid leukemia in 2026 by targeting STAT3, a signaling protein that rewires fat metabolism. Resistant leukemia cells switched on many lipid-handling programs, with STAT3 activity and its targets SREBP1 and CPT2 raised. The team also found W1307, a selective STAT3 blocker.
Blocking STAT3, by gene or drug, choked both fat making and fat burning, leaving lipids piled up, reactive oxygen rising, and cell power plants faltering. STAT3 directly switched on the genes for SREBP1 and CPT2 in their tests. W1307 also made resistant cells sensitive again to the standard drug Ara-C, in dishes and in animals. Peng and colleagues nominate W1307 for development.
Catalog record
| CREATOR | Keren Peng, Jianshan Mo, Zhenjiao Yang, Wen Ding, Jiayu Yan, Shumin Ouyang, Minyuan Lu, Kai Zhu, Hongru Yao, Huiqin Chen, Xiongjun Xu, Peibin Yue, Jinjian Lu, Yuanxiang Wang, Shanyi Zhang, Yandong Wang, Xiaolei Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74987 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |