Physical frailty, depressive symptoms, and cognitive decline before and after Parkinson’s disease diagnosis: a population-based prospective study of the SHARE and ELSA cohorts
Ziyang Ren, Zuliyaer Talifu, Xinyue Lin, Yuchun Sun, Yihao Zhao, Jing Chen, Danhua Zhao, Jufen Liu, Junliang Yuan, Xiaoying Zheng · 2026
Read Physical frailty, depressive symptoms, and cognitive decline before and after Parkinson’s disease diagnosis: a population-based prospective study of the SHARE and ELSA cohorts by Ziyang Ren, Zuliyaer Talifu, Xinyue Lin, Yuchun Sun, Yihao Zhao, Jing Chen, Danhua Zhao, Jufen Liu, Junliang Yuan, Xiaoying Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13518943.txt.
Description
Ziyang Ren and colleagues tracked frailty, low mood, and thinking decline in older adults to see how they foreshadow Parkinson disease. Published in 2026, the study followed 49,039 people aged fifty and over in a large European ageing survey, finding 624 new Parkinson cases over up to nine years. A second English ageing survey supplied a check on patterns before diagnosis.
Physical frailty more than doubled the risk of later Parkinson disease, while severe low mood and severe thinking problems each raised risk by roughly two thirds to nearly double. Risk climbed highest when all three problems struck together or when a person worsened across all three domains, while recovery toward better health lowered risk. People heading toward diagnosis also slipped faster beforehand, with a sharp worsening near diagnosis itself. The work backs repeated checks across body, mood, and mind to sharpen early risk grading.
Catalog record
| CREATOR | Ziyang Ren, Zuliyaer Talifu, Xinyue Lin, Yuchun Sun, Yihao Zhao, Jing Chen, Danhua Zhao, Jufen Liu, Junliang Yuan, Xiaoying Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |