Metabolomic signatures prior to in-hospital cardiac arrest: insights into potential therapeutic targets
Taline Lazzarin, Julia S. Nunes, Raquel S. Ballarin, Paula S. Azevedo, Filipe W. L. Pereira, Sergio A. R. de Paiva, Suzana E. Tanni, Leonardo Zornoff, Rafael Garrett, Daryl Jones, Marina A. Alves, Marcos F. Minicucci · 2026
Read Metabolomic signatures prior to in-hospital cardiac arrest: insights into potential therapeutic targets by Taline Lazzarin, Julia S. Nunes, Raquel S. Ballarin, Paula S. Azevedo, Filipe W. L. Pereira, Sergio A. R. de Paiva, Suzana E. Tanni, Leonardo Zornoff, Rafael Garrett, Daryl Jones, Marina A. Alves, Marcos F. Minicucci (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13518925.txt.
Description
Taline Lazzarin and co-authors hunt for chemical warning signs in blood drawn shortly before a hospital cardiac arrest, in a 2026 study. They pulled stored samples taken up to 48 hours before arrests at a large teaching hospital. Patients whose hearts restarted were matched with those whose did not, and the dead with survivors. A broad chemical scan then compared the groups.
Six candidate molecules differed at first pass, but careful checking left two standing. Low levels of the amino acid tryptophan tracked with death. High levels of a fat-burning byproduct tracked with failed revival and death alike. Pathway analysis pointed at faltering energy production in mitochondria and disturbed amino acid handling. The authors say measurable decay begins well before the arrest itself.
Catalog record
| CREATOR | Taline Lazzarin, Julia S. Nunes, Raquel S. Ballarin, Paula S. Azevedo, Filipe W. L. Pereira, Sergio A. R. de Paiva, Suzana E. Tanni, Leonardo Zornoff, Rafael Garrett, Daryl Jones, Marina A. Alves, Marcos F. Minicucci |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |