Inflammatory biomarkers of asymptomatic and symptomatic tuberculosis
Denis Awany, Dominique T Ariefdien, Simon C Mendelsohn, Virginie Rozot, Humphrey Mulenga, Sarah Nyangu, Michele Tameris, Tumelo Moloantoa, Austin Katona, Fernanda Maruri, Firdows Noor, Ravindre Panchia, Khuthadzo Hlongwane, Kim Stanley, Yuri F van der Heijden, Katie Hadley, Andrew- Fiore Gartland, Craig Innes, William Brumskine, Keertan Dheda, Shameem Jaumdally, Tahlia Perumal, Neil Martinson, Al Leslie, Bernard Fourie, Andriëtte Hiemstra, Stephanus T Malherbe, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Novel N Chegou, Timothy R Sterling, Mark Hatherill, Thomas J Scriba · 2026
Read Inflammatory biomarkers of asymptomatic and symptomatic tuberculosis by Denis Awany, Dominique T Ariefdien, Simon C Mendelsohn, Virginie Rozot, Humphrey Mulenga, Sarah Nyangu, Michele Tameris, Tumelo Moloantoa, Austin Katona, Fernanda Maruri, Firdows Noor, Ravindre Panchia, Khuthadzo Hlongwane, Kim Stanley, Yuri F van der Heijden, Katie Hadley, Andrew- Fiore Gartland, Craig Innes, William Brumskine, Keertan Dheda, Shameem Jaumdally, Tahlia Perumal, Neil Martinson, Al Leslie, Bernard Fourie, Andriëtte Hiemstra, Stephanus T Malherbe, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Novel N Chegou, Timothy R Sterling, Mark Hatherill, Thomas J Scriba (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13518882.txt.
Description
Denis Awany and a large team compare blood signals in 2026 between tuberculosis patients with symptoms and those found by community screening who feel well. More than half of TB cases in prevalence surveys report no classic symptoms, yet such silent disease may still spread. Whether its biology differs from symptomatic TB was unknown.
Gene and protein profiles from South African cohorts showed both forms share core patterns: innate, interferon, and inflammation pathways switched up, while T and B cell pathways switched down. Silent cases split into two clusters differing in bacterial burden and chest imaging. Marker tests performed worse for silent disease, so the authors warn against reusing symptom-based diagnostics for community screening without rework.
Catalog record
| CREATOR | Denis Awany, Dominique T Ariefdien, Simon C Mendelsohn, Virginie Rozot, Humphrey Mulenga, Sarah Nyangu, Michele Tameris, Tumelo Moloantoa, Austin Katona, Fernanda Maruri, Firdows Noor, Ravindre Panchia, Khuthadzo Hlongwane, Kim Stanley, Yuri F van der Heijden, Katie Hadley, Andrew- Fiore Gartland, Craig Innes, William Brumskine, Keertan Dheda, Shameem Jaumdally, Tahlia Perumal, Neil Martinson, Al Leslie, Bernard Fourie, Andriëtte Hiemstra, Stephanus T Malherbe, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Novel N Chegou, Timothy R Sterling, Mark Hatherill, Thomas J Scriba |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59095 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |