Single-fraction or multi-fraction stereotactic ablative body radiotherapy followed by atezolizumab in advanced triple-negative breast cancer: a randomized phase II trial
Steven David, Peter Savas, Shankar Siva, Mathias Bressel, Michelle White, Bronte Nikolic, Michael W. Neeson, Shane White, Gavin Marx, Robyn Cheuk, Michelle Grogan, Maria Farrell, Jessica Foudoulis, Paul J. Neeson, Sherene Loi · 2026
Read Single-fraction or multi-fraction stereotactic ablative body radiotherapy followed by atezolizumab in advanced triple-negative breast cancer: a randomized phase II trial by Steven David, Peter Savas, Shankar Siva, Mathias Bressel, Michelle White, Bronte Nikolic, Michael W. Neeson, Shane White, Gavin Marx, Robyn Cheuk, Michelle Grogan, Maria Farrell, Jessica Foudoulis, Paul J. Neeson, Sherene Loi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13518837.txt.
Description
Steven David and a large team report the AZTEC trial in 2026, a randomized phase II study pairing focused radiation with the immunotherapy drug atezolizumab in advanced triple-negative breast cancer. Lab evidence hints radiation can wake up body-wide anti-tumor responses, though the best radiation schedule was unknown. Fifty-four women received either one large dose or three smaller doses.
Median time without disease worsening was 2.5 months for the single-dose arm and 3.1 months for the multi-dose arm, too close to separate. Neither arm beat the two-month benchmark set in advance. Benefit lasting at least 24 weeks appeared in about a fifth to a quarter of patients, all with limited spread. Side effects were similar.
Catalog record
| CREATOR | Steven David, Peter Savas, Shankar Siva, Mathias Bressel, Michelle White, Bronte Nikolic, Michael W. Neeson, Shane White, Gavin Marx, Robyn Cheuk, Michelle Grogan, Maria Farrell, Jessica Foudoulis, Paul J. Neeson, Sherene Loi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |