Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M
Jared M Andrews, Kaitlin M Budd, Chang-Hyuk Kwon, Jon D Larson, Abbas Shirinifard, Lawryn H Kasper, Chanrika C Williams, Alfonso Lavado, Sharon King, Jorge Gutierrez, Daniel Stabley, Tong Lin, Sara A Lewis, Paul A Northcott, Arzu Onar-Thomas, Suzanne J Baker · 2026
Read Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M by Jared M Andrews, Kaitlin M Budd, Chang-Hyuk Kwon, Jon D Larson, Abbas Shirinifard, Lawryn H Kasper, Chanrika C Williams, Alfonso Lavado, Sharon King, Jorge Gutierrez, Daniel Stabley, Tong Lin, Sara A Lewis, Paul A Northcott, Arzu Onar-Thomas, Suzanne J Baker (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13518833.txt.
Description
A lethal childhood brain tumor grows almost only in the midline, and most cases carry the same histone mutation, H3.3 K27M. Jared Andrews and co-authors asked in 2026 why that mutation favors the brainstem. Using mice engineered to switch the mutation on, they compared the oligodendrocyte lineage — the tumor's cell of resemblance — across brain regions.
Brainstem precursor cells naturally grow slower and mature later than their counterparts near the cortex. The mutation widened that gap: it boosted brainstem precursor growth, held back their full maturation, and switched on signaling programs selectively there. Growth increases under the mutation were stronger in pons and hindbrain than in the forebrain. The authors conclude the mutation exploits built-in regional differences, opening a brainstem-specific window in which the tumor can start.
Catalog record
| CREATOR | Jared M Andrews, Kaitlin M Budd, Chang-Hyuk Kwon, Jon D Larson, Abbas Shirinifard, Lawryn H Kasper, Chanrika C Williams, Alfonso Lavado, Sharon King, Jorge Gutierrez, Daniel Stabley, Tong Lin, Sara A Lewis, Paul A Northcott, Arzu Onar-Thomas, Suzanne J Baker |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 99 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |