PARP inhibitor YCH1899 activates type I interferon signaling and synergizes with STING agonists in BRCA-proficient tumors
Li Jia, Ming-Hao Cao, Yu-Ting Sun, Xu-Bin Bao, Wen-Ting Zhu, Yong-Jun Cheng, Li-Min Wang, Hui Yang, Shan-Shan Song, Chang-Qing Tian, Ze-Hong Miao, Chun-Hao Yang, Jin-Xue He · 2026
Read PARP inhibitor YCH1899 activates type I interferon signaling and synergizes with STING agonists in BRCA-proficient tumors by Li Jia, Ming-Hao Cao, Yu-Ting Sun, Xu-Bin Bao, Wen-Ting Zhu, Yong-Jun Cheng, Li-Min Wang, Hui Yang, Shan-Shan Song, Chang-Qing Tian, Ze-Hong Miao, Chun-Hao Yang, Jin-Xue He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13518744.txt.
Description
A drug class that jams DNA repair kills cancers born with a broken repair gene, but shrugs at the rest. Li Jia and twelve co-authors present a next member of that class in 2026 that wakes the immune alarm even in repair-sound tumours. Loose DNA builds up in the cell's fluid under the drug, and a sensor chain reads it as invasion.
The alarm calls killer T cells into the tumour. In mice, growth of several repair-sound tumours stalls, and the effect dies if the alarm's hub is cut. A screen for the response's own brakes names one protein whose loss dulls the alarm. Pairing the drug with an alarm booster lifts the effect further. Immune heat, not just repair jam, is the new weapon.
Catalog record
| CREATOR | Li Jia, Ming-Hao Cao, Yu-Ting Sun, Xu-Bin Bao, Wen-Ting Zhu, Yong-Jun Cheng, Li-Min Wang, Hui Yang, Shan-Shan Song, Chang-Qing Tian, Ze-Hong Miao, Chun-Hao Yang, Jin-Xue He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |