A multidimensional follicular profile integrating oxidative stress, apoptosis and PI3K/AKT/mTOR signaling in relation to oocyte developmental competence in in vitro fertilization cycles
Oya Korkmaz, Seda Karabulut, Pelin Macit, İlknur Keskin · 2026
Read A multidimensional follicular profile integrating oxidative stress, apoptosis and PI3K/AKT/mTOR signaling in relation to oocyte developmental competence in in vitro fertilization cycles by Oya Korkmaz, Seda Karabulut, Pelin Macit, İlknur Keskin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13518707.txt.
Description
Oya Korkmaz led a 2026 study of thirty women having a fertility treatment in which a single sperm is placed inside each egg. The team sampled fluid from follicles, the sacs holding maturing eggs, and tracked which eggs matured, which embryos grew well, and which cycles led to pregnancy. Their aim was to test whether a panel of follicle measures could judge egg quality better than shape alone.
Follicles tied to good outcomes held more antioxidant power and less oxidative damage, with less DNA breakage in their nurse cells and healthier chromatin, the packaged form of DNA. Signals through a growth pathway called PI3K and AKT ran higher while a brake protein called mTOR ran lower. Hormones in the fluid split by role, with some linked to egg maturity and others to strong embryos and pregnancy. The work points toward richer ways of picking the most promising eggs.
Catalog record
| CREATOR | Oya Korkmaz, Seda Karabulut, Pelin Macit, İlknur Keskin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |