CLIP2::MET fusion identifies a molecularly distinct glioneuronal tumor
Jawad Fares, Jared T. Ahrendsen, Harrshavasan T. Congivaram, Lucas Santana-Santos, Daniel Oyon, Karan Dixit, Mark W. Youngblood, James P. Chandler · 2026
Read CLIP2::MET fusion identifies a molecularly distinct glioneuronal tumor by Jawad Fares, Jared T. Ahrendsen, Harrshavasan T. Congivaram, Lucas Santana-Santos, Daniel Oyon, Karan Dixit, Mark W. Youngblood, James P. Chandler (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13518623.txt.
Description
Jawad Fares and seven colleagues report a 2026 case of a brain tumor in a 19-year-old woman who came to care after a first seizure. Imaging showed a small lesion in the right frontal lobe that looked like a low-grade glioma. Tissue study found mixed glial and neuronal elements with low growth activity. Standard tests found no IDH1, IDH2, or BRAF changes, while methylation profiling matched no known tumor class.
RNA sequencing then found a CLIP2::MET fusion as the only harmful change present. Fares and the team argue that the fusion may mark a separate molecular group within glioneuronal tumors. Readers gain a worked example of broad genomic testing, plus a reminder that MET fusions can guide treatment because approved inhibitors already exist for other cancers.
Catalog record
| CREATOR | Jawad Fares, Jared T. Ahrendsen, Harrshavasan T. Congivaram, Lucas Santana-Santos, Daniel Oyon, Karan Dixit, Mark W. Youngblood, James P. Chandler |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22112 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |