Early cell-wall stress signatures enable 20-min ATR-FTIR discrimination of MRSA and MSSA
Wilbur Hudson, Michael Nelson, Caroline C Taylor, Alexander Marchesani, Diyali Sil, Chayan Dutta, Eric S Gilbert, Gary Hastings, Yi Jiang · 2026
Read Early cell-wall stress signatures enable 20-min ATR-FTIR discrimination of MRSA and MSSA by Wilbur Hudson, Michael Nelson, Caroline C Taylor, Alexander Marchesani, Diyali Sil, Chayan Dutta, Eric S Gilbert, Gary Hastings, Yi Jiang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13518314.txt.
Description
Wilbur Hudson leads a nine-author push to spot drug-resistant staph in twenty minutes in a 2026 study. Standard resistance testing takes two to three days, leaving doctors guessing at the first antibiotic. Infrared spectroscopy reads a bacterium's chemical fingerprint, and earlier work separated resistant from sensitive Staph aureus after an hour or two of drug exposure. This team asked whether twenty minutes suffices.
Seven strains bathed in weak ampicillin while spectra were taken at set marks. Models built on a few laser-picked bands classified strains with about ninety-one percent accuracy at twenty minutes, holding under the harshest test, leaving one strain out entirely. The telling bands mapped to wall-building chemistry, and microscopes confirmed walls thickening and breaking in sensitive strains only. Hudson's team calls it proof of concept for near-bedside resistance answers.
Catalog record
| CREATOR | Wilbur Hudson, Michael Nelson, Caroline C Taylor, Alexander Marchesani, Diyali Sil, Chayan Dutta, Eric S Gilbert, Gary Hastings, Yi Jiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41945 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |