Novel immune-related susceptibility loci associated with pediatric steroid-sensitive nephrotic syndrome identified by a transethnic genome-wide association study
Xueying Yang, Zijian Tian, Xueting Chen, Jian Shao, Li Wang, Fenfen Ni, Rui Liang, Bo Zhao, Shipin Feng, Xiaojie Gao, Jingjing Cui, Xia Yang, Xuelan Chen, Xiaoqin Li, Baohui Yang, Junli Wan, Jia Jiao, Anshuo Wang, Qin Yang, Xuejun Yang, Daoqi Wu, Gaofu Zhang, Mo Wang, Kaixin Zhou, Han Chan, Haiping Yang, Qiu Li · 2026
Read Novel immune-related susceptibility loci associated with pediatric steroid-sensitive nephrotic syndrome identified by a transethnic genome-wide association study by Xueying Yang, Zijian Tian, Xueting Chen, Jian Shao, Li Wang, Fenfen Ni, Rui Liang, Bo Zhao, Shipin Feng, Xiaojie Gao, Jingjing Cui, Xia Yang, Xuelan Chen, Xiaoqin Li, Baohui Yang, Junli Wan, Jia Jiao, Anshuo Wang, Qin Yang, Xuejun Yang, Daoqi Wu, Gaofu Zhang, Mo Wang, Kaixin Zhou, Han Chan, Haiping Yang, Qiu Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13518090.txt.
Description
Yang and colleagues hunt for gene clues to a childhood kidney illness that answers well to steroids. In the illness, filters in the kidney leak protein into urine. Past gene hunts were small, so much of the inherited risk stayed hidden.
The team scanned genomes of children in China, then pooled data across world groups. Two new risk spots stood out near genes tied to immune system jobs. One spot links to a gene that, when more active in immune cells, raised risk. The other links to a gene where more activity cut risk. A combined gene score also tied to illness starting at a younger age.
Catalog record
| CREATOR | Xueying Yang, Zijian Tian, Xueting Chen, Jian Shao, Li Wang, Fenfen Ni, Rui Liang, Bo Zhao, Shipin Feng, Xiaojie Gao, Jingjing Cui, Xia Yang, Xuelan Chen, Xiaoqin Li, Baohui Yang, Junli Wan, Jia Jiao, Anshuo Wang, Qin Yang, Xuejun Yang, Daoqi Wu, Gaofu Zhang, Mo Wang, Kaixin Zhou, Han Chan, Haiping Yang, Qiu Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |