Targeted Enrichment Sequencing for Wastewater Resistome Surveillance: A Proof-of-Concept Study Across Treatment Stages and Seasons
Giusy Bonanno Ferraro, David Brandtner, Carolina Veneri, Pamela Mancini, Agata Franco, Daniele Congiu, Marcello Iaconelli, Monica Monaco, Maria Del Grosso, Giulia Errico, Elisabetta Suffredini, Giuseppina La Rosa · 2026
Read Targeted Enrichment Sequencing for Wastewater Resistome Surveillance: A Proof-of-Concept Study Across Treatment Stages and Seasons by Giusy Bonanno Ferraro, David Brandtner, Carolina Veneri, Pamela Mancini, Agata Franco, Daniele Congiu, Marcello Iaconelli, Monica Monaco, Maria Del Grosso, Giulia Errico, Elisabetta Suffredini, Giuseppina La Rosa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13517800.txt.
Description
Giusy Bonanno Ferraro leads a twelve-author proof of concept for watching drug resistance in sewage in a 2026 study. Standard PCR testing finds only the resistance genes it is told to seek. A capture panel targeting nearly twenty-eight hundred resistance genes was instead run on eight paired in-and-out samples from a large central Italian treatment plant across one year.
Seven hundred forty-three resistance genes showed up on both sides of treatment. A few heavyweights made up about sixty percent of total signal, while over five hundred genes lingered at trace levels. Thirty-five drug categories were represented. Seasons mostly left the profile alone, though winter influent carried a distinct enrichment, tetracycline genes prominent, which treatment blurred. Ferraro's team argues capture sequencing gives surveillance the wide lens that fixed gene lists miss, just as European rules begin demanding such monitoring.
Catalog record
| CREATOR | Giusy Bonanno Ferraro, David Brandtner, Carolina Veneri, Pamela Mancini, Agata Franco, Daniele Congiu, Marcello Iaconelli, Monica Monaco, Maria Del Grosso, Giulia Errico, Elisabetta Suffredini, Giuseppina La Rosa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |