Serum Metabolomic Alterations and Developmental Toxicity Induced by Diquat Exposure in Pregnant Rats and Their Fetuses: A Preliminary Study
Xuelian Li, Ying Cai, Mengcao Liu, Guang Wang, Lina Gao · 2026
Read Serum Metabolomic Alterations and Developmental Toxicity Induced by Diquat Exposure in Pregnant Rats and Their Fetuses: A Preliminary Study by Xuelian Li, Ying Cai, Mengcao Liu, Guang Wang, Lina Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13517744.txt.
Description
Xuelian Li and four colleagues test the herbicide diquat on pregnant rats and their fetuses in a 2026 preliminary study. Diquat is restricted in many countries for its wider toxicity, but its effects during pregnancy are thinly mapped. Dams received repeated below-lethal doses at two levels, and the team read maternal hormones, stress chemistry, blood metabolites, and fetal skeletons.
The high dose cut estradiol while two pituitary hormones held steady. Stress markers shifted clearly, signalling oxidative strain in the mothers. Fetuses paid the heavier price: skull, breastbone, tail, and pelvis bones hardened late or not at all, with some litters affected completely. Metabolite profiles split cleanly from controls, pointing at hormone-making, amino-acid, and salt-balance pathways. Li's team presents the pattern as early evidence that diquat unsettles pregnancy chemistry and delays the fetal skeleton's build-out.
Catalog record
| CREATOR | Xuelian Li, Ying Cai, Mengcao Liu, Guang Wang, Lina Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |