Human Coronavirus Photodynamic Inactivation and In Silico Mechanisms Induced by Ga(III) vs. Zn(II) Phthalocyanines
Neli Vilhelmova-Ilieva, Emilio Mateev, Muhammed Tilahun Muhammed, Aleksandra Rangelova, Diana Braikova, Ivan Iliev, Vanya Mantareva · 2026
Read Human Coronavirus Photodynamic Inactivation and In Silico Mechanisms Induced by Ga(III) vs. Zn(II) Phthalocyanines by Neli Vilhelmova-Ilieva, Emilio Mateev, Muhammed Tilahun Muhammed, Aleksandra Rangelova, Diana Braikova, Ivan Iliev, Vanya Mantareva (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13517417.txt.
Description
Neli Vilhelmova-Ilieva leads a seven-author team testing light-activated compounds against a human coronavirus in a 2026 study. Photodynamic inactivation uses dye-like molecules plus light to flood viruses with damaging oxygen species. Two metal-bearing phthalocyanine dyes, one with gallium and one with zinc, faced the coronavirus OC43 under red light. The team measured attacks on free virus particles, on the virus's grip step, and on its copying cycle inside cells.
The zinc dye hit hardest: a four-log cut in free virus and up to complete blocking of the grip step with longer light exposure. Both dyes worked early in the copying cycle, with the zinc compound again ahead on the team's inactivation index. Computer docking added: both dyes bound plausibly to several viral proteins and to the human entry receptor. The authors present light-activated treatment as a promising anti-coronavirus route worth developing.
Catalog record
| CREATOR | Neli Vilhelmova-Ilieva, Emilio Mateev, Muhammed Tilahun Muhammed, Aleksandra Rangelova, Diana Braikova, Ivan Iliev, Vanya Mantareva |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |