Immunometabolism in HIV Reservoirs: Implications for Latency and Comorbidities
Mary-Elizabeth Zipparo, Rebecca T. Veenhuis · 2026
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Description
Mary-Elizabeth Zipparo and Rebecca T Veenhuis review how HIV rewires immune-cell metabolism in a 2026 article. Even on effective therapy, the virus hides in resting defender cells, and that hidden reservoir blocks any cure. The authors focus on the two cell families that host it: CD4 T cells and the monocyte-macrophage line. Each carries a distinct fuel-use profile during first infection, active copying, and quiet latency.
The virus favours metabolically busy cells, then rides their settling into rest to establish hiding places. Those same metabolic shifts may explain why treated people face more diabetes, heart disease, cancer, and cognitive trouble. Zipparo and Veenhuis argue that metabolism is no background noise but a lever. Targeting the fuel pathways that shelter the reservoir could support cure strategies and soften the chronic inflammation that ages patients early.
Catalog record
| CREATOR | Mary-Elizabeth Zipparo, Rebecca T. Veenhuis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43835 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |