Oligomerisation Drives Internal Cavity Formation and Conformational Heterogeneity in Mixed Triton X‐100/Tyloxapol Micelles
Hrachya Ishkhanyan, David J Barlow, M Jayne Lawrence, Christian D Lorenz · 2026
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Description
Hrachya Ishkhanyan and co-authors probe how linking soap-like molecules into chains reshapes the micelles they form. Micelles are tiny balls that surfactants build in water, used in drugs and detergents. Linked forms, called oligomeric surfactants, act at lower doses, yet their inner architecture was murky.
The team mixes Triton X-100 with its linked cousin Tyloxapol at eight blends, from pure to pure. Simulations at atom scale pair with neutron scattering checks. Rich Tyloxapol blends form flatter, tighter balls with water-filled cavities inside, as head groups dive into the core. The two soaps mix at random, with no clumping by kind. Local surroundings pick which shapes the linked molecules adopt. Shaping inner space, not just size, gives designers a new dial for micelle cargo.
Catalog record
| CREATOR | Hrachya Ishkhanyan, David J Barlow, M Jayne Lawrence, Christian D Lorenz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |