NLRP3 Inflammasome and Inflammation-Related Proteins Expression Characterized in Non-Cultivated Versus Cultivated Peripheral Blood Cells of Patients with Amyotrophic Lateral Sclerosis
Denis Shevchuk, Yulia Kuzmenko, Mariya Zakharova, Vadim Karpov, Elizaveta Starodubova, Anastasia Latanova · 2026
Read NLRP3 Inflammasome and Inflammation-Related Proteins Expression Characterized in Non-Cultivated Versus Cultivated Peripheral Blood Cells of Patients with Amyotrophic Lateral Sclerosis by Denis Shevchuk, Yulia Kuzmenko, Mariya Zakharova, Vadim Karpov, Elizaveta Starodubova, Anastasia Latanova (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13516774.txt.
Description
Denis Shevchuk and five colleagues test how handling blood cells changes inflammation readings in ALS research, in a 2026 study. The NLRP3 inflammasome, an internal alarm complex, is suspected in the nerve decay of amyotrophic lateral sclerosis. Blood immune cells could carry a readable trace of it. The team compared fresh cells with cells kept in culture, from twenty-three patients and twenty healthy controls, measuring gene and protein levels plus two alarm cytokines.
Culturing the cells lowered the gene activity of alarm parts and cytokines, though protein levels held. One alarm gene, NLRP3 itself, read higher in patient cells after culture. The cytokine IL-18 appeared in blood plasma, while IL-1β showed only in cultured-cell fluid. Shevchuk's team warns that the choice to culture or not can decide what a study sees. Handling rules therefore belong in the design of any blood-based inflammasome study.
Catalog record
| CREATOR | Denis Shevchuk, Yulia Kuzmenko, Mariya Zakharova, Vadim Karpov, Elizaveta Starodubova, Anastasia Latanova |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62839 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |