Systematic Design and Evaluation of Nasal Drug Delivery for Central Nervous System Disease from Experimental to Clinical Application
Xi-Rui Zhou, Yi Zhang, Qianqian Kong, Ziyue Wang, Yiming Luo, Hao Huang, Wensheng Qu, Zhiyuan Yu, Xiang Luo · 2026
Read Systematic Design and Evaluation of Nasal Drug Delivery for Central Nervous System Disease from Experimental to Clinical Application by Xi-Rui Zhou, Yi Zhang, Qianqian Kong, Ziyue Wang, Yiming Luo, Hao Huang, Wensheng Qu, Zhiyuan Yu, Xiang Luo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13516757.txt.
Description
Xi-Rui Zhou leads a nine-author review of nose-to-brain drug delivery in a 2026 article. The blood-brain barrier blocks nearly all small drugs, leaving brain diseases undertreated. Spraying or dropping medicine into the nose offers a side door along the smell and trigeminal nerves. The authors map those routes, then survey design strategies, formula tuning, and device engineering meant to make the trip reliable.
Their main contribution is a five-part test for clinical readiness. A candidate must aim precisely, behave predictably in the body, prove safe across organs, fit its device in real use, and translate honestly from animal noses to human ones. Scoring today's research against those pillars exposes where translation stalls. Zhou's team offers the framework as a bench-to-bedside checklist for a field rich in clever formulas and poor in finished products.
Catalog record
| CREATOR | Xi-Rui Zhou, Yi Zhang, Qianqian Kong, Ziyue Wang, Yiming Luo, Hao Huang, Wensheng Qu, Zhiyuan Yu, Xiang Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |