Molecular Insights from Differential Proteomic Profiling of Premalignant Cervical Lesions and Cervical Cancer
Diana Laura Gonzalez-Tolentino, Olga Lilia Garibay-Cerdenares, Sergio Encarnación-Guevara, Ángel Gabriel Martínez-Batallar, Ramiro Alonso-Bastida, Jeovanis Gil, Jorge Organista-Nava, Luz del Carmen Alarcón-Romero, Marco Antonio Leyva-Vázquez, Berenice Illades-Aguiar · 2026
Read Molecular Insights from Differential Proteomic Profiling of Premalignant Cervical Lesions and Cervical Cancer by Diana Laura Gonzalez-Tolentino, Olga Lilia Garibay-Cerdenares, Sergio Encarnación-Guevara, Ángel Gabriel Martínez-Batallar, Ramiro Alonso-Bastida, Jeovanis Gil, Jorge Organista-Nava, Luz del Carmen Alarcón-Romero, Marco Antonio Leyva-Vázquez, Berenice Illades-Aguiar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13516432.txt.
Description
Diana Laura Gonzalez-Tolentino leads a ten-author team profiling proteins across the road from cervical precancer to cancer in a 2026 study. Nearly all cervical cancers follow lasting infection with high-risk HPV, above all type 16. The team compared biopsies of HPV16-positive low-grade lesions and full squamous cell cancers against healthy HPV-negative cervix tissue, using high-end mass spectrometry to count thousands of proteins.
Over sixteen hundred proteins shifted in the low-grade lesions, clustering around cell grip and matrix structure. A similar count shifted in cancers, clustering around chemistry and transport work. Proteins raised in early lesions leaned toward metabolism and immune and stress responses. Those raised in cancer leaned toward cell division, DNA damage handling, and protein disposal. Two proteins, S100A10 and thymidine phosphorylase, stood out across stages and matched public gene data.
Catalog record
| CREATOR | Diana Laura Gonzalez-Tolentino, Olga Lilia Garibay-Cerdenares, Sergio Encarnación-Guevara, Ángel Gabriel Martínez-Batallar, Ramiro Alonso-Bastida, Jeovanis Gil, Jorge Organista-Nava, Luz del Carmen Alarcón-Romero, Marco Antonio Leyva-Vázquez, Berenice Illades-Aguiar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |